SGLT2 inhibitor

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HRS-7535: A Promising Oral GLP-1 Receptor Agonist for Type 2 Diabetes Uncontrolled by Metformin and SGLT2 Inhibitors

This Phase II trial demonstrates that HRS-7535, an oral small-molecule GLP-1 receptor agonist, significantly improves glycaemic control and is well-tolerated in type 2 diabetes patients inadequately controlled with metformin and SGLT2 inhib

Oct 19, 2026

Diabetes & Endocrinology

Targeting Mitochondria: A Practical Algorithm for Diabetes Care in Maternally Inherited Diabetes and Deafness (MIDD)

Maternally inherited diabetes and deafness (MIDD) is driven by m.3243A>G mitochondrial mutation with mixed β‑cell failure and insulin resistance. GLP‑1 receptor agonists and SGLT2 inhibitors have biologic plausibility and cardiorenal ben

Nov 4, 2025

Clinical Updates

Dapagliflozin Shows Promising Benefits for Patients with Metabolic Dysfunction-Associated Steatohepatitis (MASH): A Landmark Multicentre Trial

Dapagliflozin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis outcomes without increasing adverse events, according to a rigorous 48-week randomized trial.

Aug 13, 2025