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restrictive transfusion

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Hematology-Oncology

Restrictive versus Liberal Transfusion Thresholds in Very Low Birthweight Infants: Fewer Transfusions Without Harm to Survival or Early Neurodevelopment

A Cochrane meta-analysis of six RCTs (3,451 infants) finds restrictive hemoglobin thresholds reduce transfusion exposure modestly with no detectable effect on mortality or neurodevelopmental impairment at 18–26 months.

Dec 12, 2025
Anesthesiology

Restrictive Red Blood Cell Transfusion Is Safe for Most Patients — Except in Neurocritical Care (and Some Bleeding Syndromes)

A Cochrane update (2025) of 69 randomized trials found restrictive RBC transfusion thresholds (typically Hb 7–8 g/dL) cut transfusion exposure ~42% without increasing 30‑day mortality overall, but liberal strategies improved long‑term neuro

Nov 6, 2025

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