respiratory drive

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Modulation of Respiratory Drive by Ondansetron in Acute Respiratory Distress Syndrome: Emerging Evidence and Clinical Implications

Ondansetron, a 5-HT3 antagonist, reduces respiratory drive in ARDS patients on mechanical ventilation by attenuating pulmonary C-fiber mediated stimulation, potentially lessening lung injury and improving oxygenation.

Oct 14, 2026

Critical Care

Both Too Little and Too Much Respiratory Drive and Effort Predict Worse Outcomes on Mechanical Ventilation: Insights from a Prospective Toronto Cohort

A prospective registry study found a U-shaped relationship between respiratory drive/effort and ICU outcomes: both low and high drive/effort linked with higher mortality and slower discharge, especially when oxygenation (PaO2:FiO2) ≤150 mmH

Dec 1, 2025