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Antifibrotic Repurposing: How Finerenone Could Rejuvenate the Ovarian Niche and Restore Fertility in POI
Internal MedicinefinerenonePremature ovarian insufficiency

Antifibrotic Repurposing: How Finerenone Could Rejuvenate the Ovarian Niche and Restore Fertility in POI

By MedXY|Feb 7, 2026

A breakthrough study in Science reveals that the antifibrotic drug finerenone restores fertility in premature ovarian insufficiency (POI) by reducing ovarian stromal fibrosis, enabling follicle development where hormone therapy previously f

Does Size Matter? Re-evaluating Endometrial Thickness Thresholds in 30,000 Euploid Embryo Transfers
newsChuyển giao phôi đông lạnhreproductive medicine

Does Size Matter? Re-evaluating Endometrial Thickness Thresholds in 30,000 Euploid Embryo Transfers

By MedXY|Dec 26, 2025

An international multicenter study confirms that endometrial thickness below 7 mm reduces live birth rates in most frozen embryo transfer protocols, though the impact is notably absent in natural cycles and overall predictive power remains

Challenging the Compaction Paradigm: Why Endometrial Thinning May Not Predict Pregnancy Success in HRT-FET
newsreproductive medicine妊娠成績

Challenging the Compaction Paradigm: Why Endometrial Thinning May Not Predict Pregnancy Success in HRT-FET

By MedXY|Dec 26, 2025

A large-scale analysis of over 16,000 cases reveals that endometrial compaction following progesterone administration does not improve pregnancy outcomes in HRT-FET, and may even be associated with lower success rates in blastocyst transfer

Rethinking Mosaicism: Why Reporting Putative Mosaic Embryos Fails to Improve IVF Outcomes
newsIVFMosaicism

Rethinking Mosaicism: Why Reporting Putative Mosaic Embryos Fails to Improve IVF Outcomes

By MedXY|Dec 24, 2025

A large, double-blinded study reveals that reporting embryo mosaicism (ICN) during PGT-A provides no meaningful clinical predictive value for live birth rates, suggesting that current classification systems may unnecessarily limit embryo se

Optimising Ovulation Timing in Intrauterine Insemination: Evidence Still Unclear
newsreproductive medicine

Optimising Ovulation Timing in Intrauterine Insemination: Evidence Still Unclear

By MedXY|Dec 18, 2025

A Cochrane review finds no definitive evidence on the best method to synchronise insemination with ovulation in subfertile couples undergoing IUI.

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