real-world evidence

Latest news

Tag

Real-world data suggest nirsevimab reduces RSV test-positivity up to 12 months but not beyond — cautious interpretation required

A multicentre retrospective TriNetX analysis found reduced odds of RSV test-positivity for infants receiving nirsevimab when last dose was within 6–11 months before testing; protection was strongest within 6 months and not evident beyond 12

Nov 10, 2025Sign in to read

Gastroenterology

Long-Term Real-World Effectiveness, Safety, and Liver Stiffness Changes with Obeticholic Acid in Primary Biliary Cholangitis

This study confirms the sustained effectiveness and safety of obeticholic acid (OCA) in primary biliary cholangitis (PBC) over a 2-year median follow-up, highlighting its impact on liver stiffness and fibrosis progression, especially in bio

Oct 28, 2025Sign in to read

Internal Medicine

Real-World Insights into HER2-Positive Metastatic Breast Cancer Treatments: Comparing T-DXd, T-DM1, and Tucatinib

This study uses real-world data to compare the effectiveness and safety of trastuzumab deruxtecan versus trastuzumab emtansine and tucatinib in HER2-positive metastatic breast cancer, confirming their clinical value.

Oct 18, 2025Sign in to read

General Surgery

Harnessing Pragmatic Clinical Trial Designs to Advance Surgical Research

Pragmatic clinical trials offer innovative solutions to overcome unique challenges in surgical research, enhancing evidence quality and applicability by integrating flexible, routine-care-based trial designs and leveraging real-world data.

Oct 10, 2025