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The UK-ROX randomized trial (n=16,500) found that targeting SpO2 90% (88–92%) to reduce oxygen exposure did not reduce 90‑day all‑cause mortality versus usual care in mechanically ventilated adults.
The KIWE randomised trial (Lancet Neurol 2023) found no superiority of a classic ketogenic diet over an additional antiseizure medication for seizure frequency in infants (1–24 months) with drug‑resistant epilepsy; tolerability and safety p
Adding a very-low-calorie diet to exercise yields no additional pain relief for overweight or obese adults with hip osteoarthritis, despite greater weight loss.
A Danish multicentre trial found individualised, shorter antibiotic regimens for febrile pediatric UTIs reduce overall antibiotic exposure and adverse events, but with a modestly higher recurrence risk compared to standard 10-day treatment.
Large-scale trials show that routine cerebral embolic protection during TAVI does not significantly reduce early stroke rates, though selective benefits in major stroke and secondary outcomes may exist.
A large multinational trial found that acute normovolemic hemodilution (ANH) did not significantly reduce allogeneic red-cell transfusion in adult cardiac surgery patients, with similar safety outcomes compared to usual care.
A randomized trial demonstrates that medial opening wedge high tibial osteotomy (HTO) slows cartilage loss and improves symptoms in patients with medial compartment knee osteoarthritis and varus alignment, supporting its role as a joint-pre
A large US trial found that structured, intensive lifestyle interventions led to greater improvements in global cognition over two years compared to self-guided approaches among older adults at risk for cognitive decline.
