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This study reveals significantly reduced ACE protein levels in cerebrospinal fluid and serum of early-stage psychosis patients, particularly in treatment-resistant cases, highlighting a potential biomarker and mechanistic role beyond enzyma
The STAR trial demonstrates that trauma-focused CBTp is a safe, effective intervention for adults with co-occurring PTSD and psychosis, improving PTSD and psychosis symptoms, with high acceptability and minimal adverse events.
A multimethod study suggests that delusions in first-episode psychosis are ’embodied emotions’—global transformations of self-experience shaped by life narratives, particularly early shame and trauma. This research challenges tr
A cross-sectional study of never-medicated individuals reveals that elevated medial prefrontal cortex glutamate levels are specific to the first episode of psychosis and correlate with cognitive deficits, suggesting a critical window for gl
Researchers developed a clinical prediction model using electronic health records from over 127,000 patients to identify individuals at risk of psychotic or bipolar disorders. The model demonstrated high discriminative power (C-index 0.80)
This study reveals that genetic predispositions interact with anticholinergic medication burden to influence cognitive deficits and brain gray matter volume reductions in psychosis spectrum disorders, offering new insights into personalized
