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Psychedelics and MDMA for Mental Disorders: Promising Large Effects but Limited Certainty—What the Latest Living Meta-analysis Shows
newsmajor depressionMDMA

Psychedelics and MDMA for Mental Disorders: Promising Large Effects but Limited Certainty—What the Latest Living Meta-analysis Shows

By MedXY|Nov 25, 2025

A living systematic review of 30 RCTs (n=1,480) finds moderate-to-large symptom reductions for MDMA in PTSD and serotonergic psychedelics in major depression and anxiety, but high risk of bias and low certainty overall; pragmatic, longer, a

Psychedelics Target Neuroimmune Interactions to Limit Fear
Allergy & Immunologyamygdaladepression

Psychedelics Target Neuroimmune Interactions to Limit Fear

By MedXY|Oct 1, 2025

Research reveals how psychedelics modulate immune-to-brain communication to reduce fear, offering new therapeutic avenues for stress-related psychiatric disorders.

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