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A 20-year observational study reveals near-universal long-term proton pump inhibitor use in lung transplant recipients without demonstrable improvements in graft function or survival, challenging routine PPI prescriptions in this population
A study reveals a higher prevalence of rapid CYP2C19 metabolizer phenotypes in GERD patients undergoing surgery versus medical therapy, supporting tailored proton pump inhibitor dosing and timely surgical referral.
This study evaluates the effectiveness of an antireflux diet combined with stress reduction against proton pump inhibitors, alginates, and antacids in treating laryngopharyngeal reflux disease, revealing diet adherence may offer superior sy
A large primary care trial found that a combined patient- and GP-focused deprescribing intervention safely reduced long-term proton pump inhibitor use more effectively than usual care or GP-only education.
This systematic review and meta-analysis of randomized controlled trials finds no significant association between proton pump inhibitor use and increased risk of Clostridioides difficile infection, challenging earlier observational data and