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Activity of PROTAC MDM2 Degrader in Primary Leukemia Cells and PDX Models
Hematology-OncologyAMLBệnh Bạch Cầu Tế Bào Phôi

Activity of PROTAC MDM2 Degrader in Primary Leukemia Cells and PDX Models

By MedXY|May 27, 2026

MD-265, a PROTAC MDM2 degrader, showed strong anti-leukemia activity in primary AML cells and mouse PDX models, outperformed a conventional MDM2 inhibitor, and spared normal stem cells relatively well.

Vepdegestrant: A Next-Generation Oral PROTAC ER Degrader for Advanced ER+/HER2– Breast Cancer—VERITAC-2 Results and Clinical Implications
Clinical Updatesbreast cancerendocrine resistance

Vepdegestrant: A Next-Generation Oral PROTAC ER Degrader for Advanced ER+/HER2– Breast Cancer—VERITAC-2 Results and Clinical Implications

By MedXY|Oct 1, 2025

Vepdegestrant, an oral PROTAC estrogen receptor degrader, significantly prolongs progression-free survival compared to fulvestrant in ESR1-mutant advanced breast cancer, but not in the overall ER+/HER2– population.

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