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Infectious Diseases

Single low‑dose primaquine (0.25 mg/kg) is safe and effective for blocking Plasmodium falciparum transmission in children and adults

A pooled individual‑patient meta‑analysis (6056 participants) shows single low‑dose primaquine (0.25 mg/kg) added to ACTs reduces gametocyte carriage and mosquito infectivity across ages and transmission settings without increasing clinical

Nov 23, 2025Sign in to read
Clinical Updates

Efficacy and Safety of High-Dose Versus Low-Dose Primaquine for Plasmodium vivax in Cambodia: A Randomised Controlled Trial

A Cambodian study shows that a 14-day high-dose primaquine regimen (7.0 mg/kg) significantly reduces Plasmodium vivax relapse compared to the standard low-dose (3.5 mg/kg), with comparable safety in G6PD-normal patients.

Aug 2, 2025

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