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PPAR agonist

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Gastroenterology

Saroglitazar in Primary Biliary Cholangitis: Insights from a Phase 2b/3 Adaptive Randomized Trial

Saroglitazar, a dual PPAR α/γ agonist, demonstrated significant biochemical improvement and ALP normalization in primary biliary cholangitis patients refractory or intolerant to UDCA, with favorable safety over 52 weeks in a phase 2b/3 tria

Nov 2, 2026
Gastroenterology

Elafibranor Shows Promise as a Safe and Effective Therapy for Primary Sclerosing Cholangitis: Insights from the Phase II ELMWOOD Trial

The phase II ELMWOOD trial demonstrates that elafibranor, a dual PPAR-α/δ agonist, is well tolerated and significantly improves biochemical markers in patients with primary sclerosing cholangitis over 12 weeks, warranting further investigat

Oct 29, 2025Sign in to read

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