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Genomic testing holds promise for guiding preventive strategies in psychiatry, particularly in high-risk and clinically uncertain contexts; however, current evidence supports targeted rather than universal approaches.
Polygenic scores can predict type 1 diabetes risk after gestational diabetes, especially when combined with clinical factors, but show limited utility for type 2 diabetes prediction.
A large Danish genetic study suggests recurrent CNVs and polygenic scores provide complementary psychiatric risk information, with polygenic scores often identifying more at-risk individuals and potentially modifying CNV-associated risk.
A large Danish register and genetic study shows overlapping but distinct environmental and genetic risk factors for nonfatal suicide attempts and death by suicide, with chronic and functional health problems linked more to attempts and seve
This study reveals that genetic predispositions interact with anticholinergic medication burden to influence cognitive deficits and brain gray matter volume reductions in psychosis spectrum disorders, offering new insights into personalized