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Cardiology

GLI1 Activation in Intermittent Hypoxia: A Novel Mechanistic Link Driving Cardiac Fibrosis in Obstructive Sleep Apnea

This study reveals that intermittent hypoxia activates GLI1 transcription factor in cardiac fibroblasts, driving fibrosis via PKM2-mediated glycolysis, and highlights GLI1 as a promising therapeutic target in OSA-associated cardiac dysfunct

Aug 24, 2026
Cardiology

Targeting S-Nitrosylated PKM2: A Novel Therapeutic Frontier in Cardiac Fibrosis and Mitochondrial Dynamics

Recent evidence identifies S-nitrosylation of Pyruvate Kinase M2 (PKM2) as a specific driver of cardiac fibrosis, suggesting that activating PKM2 with drugs like mitapivat could provide a long-sought therapeutic approach for heart failure p

Mar 3, 2026Sign in to read

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