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Denosumab Shows Insufficient Activity in Recurrent Osteosarcoma: Results from a Children’s Oncology Group Phase 2 Trial
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Denosumab Shows Insufficient Activity in Recurrent Osteosarcoma: Results from a Children’s Oncology Group Phase 2 Trial

By MedXY|Jan 11, 2026

A Phase 2 trial by the Children’s Oncology Group found that denosumab, despite its success in other bone-related conditions, failed to meet efficacy benchmarks for recurrent or refractory osteosarcoma, showing no objective responses i

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SMARCAL1 Emerges as a Novel Osteosarcoma Predisposition Gene: Large Study Validates DNA Repair Variation in Pediatric Cancer Risk

By MedXY|Dec 10, 2025

A large case-control analysis of 189 DNA damage response genes in nearly 6,000 children with cancer identifies enrichment of pathogenic variants in DDR genes and nominates SMARCAL1 as a replicated osteosarcoma predisposition gene

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