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Rapid Ultraoxygenated Recovery Eliminates the Need for Preimplant Reanimation in DCD Heart Transplants
Cardiologyorgan preservation

Rapid Ultraoxygenated Recovery Eliminates the Need for Preimplant Reanimation in DCD Heart Transplants

By MedXY|Feb 9, 2026

A JAMA study demonstrates that Rapid Ultraoxygenated Recovery (REUP) enables successful DCD heart transplantation without preimplant reanimation, achieving 96% survival despite extended ischemic times and older donors, potentially offering

Total Neoadjuvant Therapy Enables Organ Preservation Without Compromising Distant Control in pMMR/MSS Stage II–III Rectal Cancer: Insights from the NO-CUT Trial
Gastroenterologynon-operative managementorgan preservation

Total Neoadjuvant Therapy Enables Organ Preservation Without Compromising Distant Control in pMMR/MSS Stage II–III Rectal Cancer: Insights from the NO-CUT Trial

By MedXY|Nov 29, 2025

The NO-CUT phase 2 trial shows that total neoadjuvant therapy (CAPOX-based TNT) followed by non-operative management for clinical complete responders achieved high 30‑month distant relapse‑free survival (95%) and enabled organ preservation

Advancing Organ Preservation in Locally Advanced Rectal Cancer: Insights from the CAO/ARO/AIO-16 Phase 2 Trial
Clinical Updatesorgan preservationrectal cancer

Advancing Organ Preservation in Locally Advanced Rectal Cancer: Insights from the CAO/ARO/AIO-16 Phase 2 Trial

By MedXY|Oct 3, 2025

Total neoadjuvant therapy combined with watch-and-wait strategies achieves a 37% clinical complete response rate in locally advanced rectal cancer with manageable toxicity, offering an organ-preserving alternative to surgery.

Expanding Nonoperative Management in Mismatch Repair–Deficient Early-Stage Solid Tumors: Phase 2 Evidence for Neoadjuvant PD-1 Blockade
Clinical UpdatesdMMRorgan preservation

Expanding Nonoperative Management in Mismatch Repair–Deficient Early-Stage Solid Tumors: Phase 2 Evidence for Neoadjuvant PD-1 Blockade

By MedXY|Sep 30, 2025

Neoadjuvant PD-1 blockade with dostarlimab enabled organ preservation and high recurrence-free survival in early-stage mismatch repair–deficient (dMMR) solid tumors, extending nonoperative management beyond rectal cancer.

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