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Predicting Opioid Use Disorder and Overdose Risk in Older Adults: Evaluating Prognostic Models
Internal Medicinechronic painolder adults

Predicting Opioid Use Disorder and Overdose Risk in Older Adults: Evaluating Prognostic Models

By MedXY|Jul 21, 2026

This study develops and compares predictive models incorporating claims and patient-reported data to forecast time to first opioid use disorder (OUD) or overdose (OD) among older adults with chronic pain on opioids, identifying key risk fac

Peer Support After Opioid Overdose: Randomized Trial Finds No Reduction in Future Adverse Events
Emergency Medicineemergency medicineharm reduction
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Peer Support After Opioid Overdose: Randomized Trial Finds No Reduction in Future Adverse Events

By MedXY|Feb 11, 2026

A randomized clinical trial of the Relay peer-navigator intervention in New York City found no significant reduction in opioid-related adverse events compared to standard care, despite high patient satisfaction and the intervention’s

Novel Benzodiazepines Intensify Opioid Overdose Severity: A Multicenter ED Study
Anesthesiologymechanical ventilationopioid overdose

Novel Benzodiazepines Intensify Opioid Overdose Severity: A Multicenter ED Study

By MedXY|Oct 6, 2025

Novel benzodiazepine coexposure in opioid overdoses significantly increases the risk of mechanical ventilation and naloxone nonresponse, highlighting a critical challenge in emergency care management.

Synthetic Opioid Overdose Deaths Among Youth Surge 168%: A Five-Year Analysis and Clinical Implications
Clinical Updatesfentanylharm reduction

Synthetic Opioid Overdose Deaths Among Youth Surge 168%: A Five-Year Analysis and Clinical Implications

By MedXY|Sep 30, 2025

Overdose deaths from synthetic opioids alone in U.S. youth aged 15–24 surged 168% between 2018 and 2022, now representing one-third of all youth OD fatalities. Clinical vigilance, harm reduction, and targeted prevention are urgently needed.

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