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Your Nose Knows: How Smell Loss Signals More Than a Cold — Links to 139 Diseases and What to Do About It
Neurologyneurologyolfaction

Your Nose Knows: How Smell Loss Signals More Than a Cold — Links to 139 Diseases and What to Do About It

By MedXY|Dec 13, 2025

A large prospective study links smell disturbances to at least 139 conditions. Olfactory loss can be an early sign of neurological, ENT, metabolic, or systemic disease — and a practical, underused screening tool clinicians can adopt.

APOE ε4, Age and Sex Converge to Disturb Anterior Olfactory Nucleus Physiology: Electrophysiologic Evidence for Early Alzheimer’s Vulnerability
NeurologyAPOE ε4olfaction

APOE ε4, Age and Sex Converge to Disturb Anterior Olfactory Nucleus Physiology: Electrophysiologic Evidence for Early Alzheimer’s Vulnerability

By MedXY|Nov 5, 2025

In vivo awake recordings in transgenic mice show APOE ε4 reduces neuronal excitability in the anterior olfactory nucleus (AON); adult females are more excitable than males (a sex difference lost with aging), while aging amplifies network os

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