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non-inferiority trial

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Gastroenterology

Shortening Sofosbuvir-Velpatasvir Therapy for Non-Cirrhotic Chronic Hepatitis C: Evidence from the RESOLVE Trial in India

The RESOLVE trial demonstrates that 8 weeks of sofosbuvir-velpatasvir treatment is non-inferior to the standard 12-week regimen in treatment-naive, non-cirrhotic chronic hepatitis C patients, supporting shorter treatment duration without co

Oct 21, 2026
news

Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy Versus Right Unilateral Ultra-Brief Electroconvulsive Therapy in Depression

Magnetic seizure therapy was non-inferior to right unilateral ultra-brief ECT for depression remission and caused less autobiographical memory worsening, suggesting a promising convulsive treatment option with better cognitive safety.

Jun 2, 2026
Anesthesiology

Remimazolam Besylate Matches Propofol for Short-Term ICU Sedation: The SHOSREB Trial

The SHOSREB trial demonstrates that remimazolam besylate is non-inferior to propofol for short-term light sedation in mechanically ventilated ICU patients, with both agents achieving 97.5% successful sedation rates and comparable time withi

Apr 13, 2026
Cardiology

X-CircuiT versus Conventional Exercise in Home-Based Cardiac Rehabilitation: A Non-Inferiority Randomized Trial for CAD Patients

This randomized controlled non-inferiority trial demonstrates that X-CircuiT, a smartphone-guided multi-component exercise regime, is as effective and safe as conventional exercise in improving fitness in home-based cardiac rehabilitation f

Oct 23, 2025
Gastroenterology

Evaluating the Necessity of Live Microbes in Fecal Microbiota Transplantation for C. difficile Recurrence: Insights from a Non-Inferiority Trial

This study investigates whether sterile lyophilised fecal filtrate is as effective as traditional donor stool in preventing recurrent C. difficile infection, highlighting the importance of live microbes in treatment efficacy.

Oct 18, 2025Sign in to read
Clinical Updates

Postoperative Radioiodine Ablation in Low-Risk Differentiated Thyroid Cancer: Insights from the IoN Trial

The IoN trial demonstrates that postoperative radioiodine ablation can be safely omitted in most patients with low-risk differentiated thyroid cancer after total thyroidectomy, without compromising recurrence-free survival.

Aug 2, 2025

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    Precision Medicine for Long QT Syndrome Type 2: Lumacaftor Corrects Trafficking Defects and Shortens QT Interval

  5. 05General Surgery

    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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