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A JCI study links recessive CPD missense variants to congenital deafness, defines a pathogenic mechanism through impaired arginine–NO–cGMP signaling with ER stress and apoptosis, and shows rescue in models with arginine or sildenafil — offe
Flexovital, a nitric oxide-enhancing supplement, effectively attenuates metabolic, cardiovascular, and renal dysfunctions in a mouse model of cardiovascular-kidney-metabolic syndrome induced by unilateral nephrectomy and Western diet.
Eight weeks of nitrate-rich beetroot extract supplementation significantly increases fasting nitrate and nitrite levels, improving knee extensor muscle strength and power in postmenopausal women.
Dietary nitrate supplementation alters age-related oral microbiome changes, enhancing nitric oxide bioavailability and reducing blood pressure in older adults, highlighting a novel mechanism for vascular health improvement.
Recent research reveals that dietary supplementation with pumpkin seeds significantly improves male erectile function by modulating key biological regulators, providing a natural and safe alternative to traditional ED medications.
Perioperative nitric oxide administration in CKD patients undergoing cardiac surgery significantly reduces acute kidney injury incidence and preserves renal function, while demonstrating safety and additional benefits against postoperative
Acute tetrahydrobiopterin (BH4) administration improves locomotor muscle microvascular function in heart failure patients, highlighting the nitric oxide pathway as a promising therapeutic target, while acute antioxidant therapy showed no be
