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Intravenous Nicorandil in STEMI Patients Undergoing Primary PCI: Insights from the CLEAN Randomized Clinical Trial and Broader Evidence
CardiologySTEMIprimary PCI

Intravenous Nicorandil in STEMI Patients Undergoing Primary PCI: Insights from the CLEAN Randomized Clinical Trial and Broader Evidence

By MedXY|Aug 17, 2026

The CLEAN trial shows intravenous nicorandil adjunctive to primary PCI does not significantly improve 12-month clinical outcomes in STEMI. Evidence suggests microvascular benefits but no consistent long-term mortality or infarct size reduct

Comparative Effects of Nicorandil, Isosorbide Mononitrate, and Diltiazem on Radial Artery Graft Patency After CABG: Insights from the ASRAB-Pilot Trial
Cardiology
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graft failure

Comparative Effects of Nicorandil, Isosorbide Mononitrate, and Diltiazem on Radial Artery Graft Patency After CABG: Insights from the ASRAB-Pilot Trial

By MedXY|Oct 3, 2025

The ASRAB-Pilot trial demonstrates that nicorandil and isosorbide mononitrate reduce radial artery graft failure rates post-CABG compared to diltiazem, highlighting potential advances in antispastic therapy for graft preservation.

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