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Unraveling the S1P-TREM2 Axis: A Novel Ferroptosis-Resistance Mechanism Driving Immunosuppressive Neutrophils and Tumour Progression in Hepatocellular Carcinoma
Gastroenterologyferroptosisimmunotherapy resistance

Unraveling the S1P-TREM2 Axis: A Novel Ferroptosis-Resistance Mechanism Driving Immunosuppressive Neutrophils and Tumour Progression in Hepatocellular Carcinoma

By MedXY|Sep 12, 2026

This study reveals how the S1P-TREM2-NRF2 signaling pathway protects tumor-associated neutrophils from ferroptosis, sustaining immunosuppression and promoting hepatocellular carcinoma progression, offering new therapeutic avenues.

Targeting Retinoic Acid-Driven CD16hiCD177+ Neutrophils in Steroid-Resistant GI-GVHD: A Novel Therapeutic Avenue
Gastroenterology
neutrophils

Targeting Retinoic Acid-Driven CD16hiCD177+ Neutrophils in Steroid-Resistant GI-GVHD: A Novel Therapeutic Avenue

By MedXY|Sep 9, 2026

Retinoic acid-driven expansion of CD16hiCD177+ neutrophils mediates steroid-resistant gastrointestinal graft-versus-host disease (GI-GVHD). Inhibition of the retinoic acid receptor restores steroid sensitivity and improves outcomes in murin

Decoding the Pulmonary Immune Landscape in Influenza: Insights from a Large-Scale Single-Cell Atlas
Infectious Diseasesalveolar macrophagesinfluenza

Decoding the Pulmonary Immune Landscape in Influenza: Insights from a Large-Scale Single-Cell Atlas

By MedXY|Jul 17, 2026

A comprehensive single-cell atlas of lung immune cells reveals distinct immune responses in mild versus severe influenza, highlighting neutrophil dysfunction and lymphocyte impairment as key drivers of pathology.

newschildhood asthmaEosinophils

Early Neutrophil and Persistent Eosinophil Gene Signatures in Childhood Asthma

By MedXY|Jun 19, 2026

A longitudinal blood gene-expression study in children found an early neutrophil-driven immune pattern at age 1, followed by a persistent eosinophilic signature from 4.5 to 10.5 years in those who later developed asthma.

Adipocyte-Driven Immunometabolic Suppression in Pancreatic Cancer: The 12,13-DiHOME/PPARγ/TAN Axis
Clinical UpdatesAdipocytesferroptosis

Adipocyte-Driven Immunometabolic Suppression in Pancreatic Cancer: The 12,13-DiHOME/PPARγ/TAN Axis

By MedXY|Jun 4, 2026

This review explores how tumour-infiltrating adipocytes release 12,13-DiHOME to trigger neutrophil ferroptosis and CXCL2 production, ultimately subverting CD8+ T cell-mediated immunity in pancreatic ductal adenocarcinoma.

Neutrophil Counts and Type 2 Diabetes Remission: Long-Term Benefits of Mediterranean Diet in Coronary Heart Disease Patients from the CORDIOPREV Study
CardiologyCoronary heart diseaseMediterranean diet

Neutrophil Counts and Type 2 Diabetes Remission: Long-Term Benefits of Mediterranean Diet in Coronary Heart Disease Patients from the CORDIOPREV Study

By MedXY|Oct 8, 2025

Lower neutrophil counts predict greater type 2 diabetes remission with a Mediterranean diet in coronary heart disease patients, highlighting immune involvement in metabolic improvement over 5 years.

Association of Testosterone-Induced Neutrophil and Monocyte Elevation with Thromboembolic Risk: Insights from the TRAVERSE Trial
Cardiologycardiovascular riskmonocytes

Association of Testosterone-Induced Neutrophil and Monocyte Elevation with Thromboembolic Risk: Insights from the TRAVERSE Trial

By MedXY|Oct 5, 2025

The TRAVERSE trial reveals that testosterone replacement therapy elevates neutrophil and monocyte counts in hypogonadal men, correlating with increased venous thromboembolism and cardiovascular event risk, underscoring the need to monitor t

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