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Kynurenic acid (KYNA) reduction in the gut correlates with worse poststroke outcomes. Supplementation activates a gut-brain neural circuit via GPR35 and the vagus nerve, promoting neuroprotection and functional recovery after ischemic strok
Cilostazol promotes dural lymphatic remodeling and hematoma clearance post-ICH without increasing bleeding risk, representing a promising therapeutic strategy to improve neurological outcomes.
Antenatal magnesium sulfate (MgSO4) use before very preterm birth significantly improves survival free of cerebral palsy and moderate-severe impairment, with evidence from randomized trials and large cohort data supporting enhanced neuropro
Systemic nicotinamide supplementation is associated with reduced risk of POAG development in ocular hypertension, improved retinal function, and better quality of life, suggesting its neuroprotective potential as an adjunctive therapy in gl
This translational study demonstrates that the FKBP5 protein, a regulator of the stress response, significantly influences stroke outcomes. Lower FKBP5 levels correlate with smaller brain lesions in mice, while high-expression genetic varia
This review evaluates a recent 2-year pilot RCT on low-dose lithium carbonate for MCI, synthesizing its findings with emerging evidence on Aβ clearance, gut-brain axis modulation, and multimodal disease forecasting.
This pilot randomized clinical trial investigated low-dose lithium for Mild Cognitive Impairment (MCI). While primary outcomes regarding cognition and neuroimaging were not statistically significant, the study established the intervention&#
The EMPHASIS trial reveals that oral minocycline initiated within 72 hours of an acute ischaemic stroke significantly enhances functional independence at 90 days. This multicentre study provides robust evidence for a well-tolerated, accessi
A randomized trial demonstrates that standardized treatment guided by cerebral oximetry reduces cerebral oxygenation instability by over 40% in extremely preterm infants, offering a precise new strategy for neonatal neuroprotection.
This Phase 2/3 trial of QPI-1007 for NAION found that while the primary endpoint was not met for the general population, the siRNA therapy significantly preserved vision in patients with more severe baseline visual impairment.
The Phase 2b ELAD trial investigated liraglutide’s efficacy in mild-to-moderate Alzheimer’s disease. While it failed its primary metabolic endpoint, significant improvements in executive function suggest a nuanced role for GLP-1
The multicenter TASTE-2 trial reveals that edaravone dexborneol significantly increases the likelihood of functional independence at 90 days for acute ischaemic stroke patients undergoing thrombectomy, particularly those presenting with a c
A large-scale retrospective cohort study reveals that GLP-1 receptor agonists reduce the risk of subarachnoid hemorrhage by 34% and all-cause mortality by 37% in patients with type 2 diabetes and intracranial aneurysms, suggesting a potent
The POP-HT randomized clinical trial imaging substudy demonstrates that intensive postpartum blood pressure management after hypertensive pregnancy is associated with significantly larger white matter and subcortical brain volumes, suggesti
Two Phase 3 trials show that NT-501 encapsulated cell therapy significantly reduces ellipsoid zone area loss in Macular Telangiectasia Type 2. While functional outcomes were inconsistent, the treatment demonstrated a robust neuroprotective
This review synthesizes preclinical evidence on electroacupuncture’s mechanisms in ischemic stroke, highlighting its therapeutic potential and factors influencing efficacy.
This review synthesizes recent PubMed-indexed evidence on remote ischemic preconditioning (RIPC) demonstrating its protective effects on cardiac and cerebral ischemia, highlighting clinical trial progress, mechanistic insights, and therapeu
This review synthesizes recent evidence demonstrating that high-intensity interval training (HIIT) confers cardiometabolic benefits, modulates microvascular and neural function, enhances insulin sensitivity, and improves mental health outco
This review synthesizes recent evidence on the benefits of high-intensity interval training (HIIT) on cardiovascular health, diabetes management, metabolic function, and neuroprotection, highlighting mechanistic insights and clinical implic
Weekly darbepoetin in extremely preterm infants increases red cell mass and reduces transfusion needs, but does not improve cognitive outcomes at 22-26 months’ corrected age.