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Linarin shows promise in mitigating NAFLD by enhancing autophagy via PI3K/Akt/mTOR inhibition, reducing inflammation, and restoring gut microbiota balance, alongside activating the PDE4D/cAMP/PKA/CREB pathway to improve hepatic lipid metabo
Dapagliflozin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis outcomes without increasing adverse events, according to a rigorous 48-week randomized trial.
Recent trials show intermittent calorie restriction (ICR) significantly reduces liver fat content in MASLD and NAFLD, especially in obese patients, offering an effective and well-tolerated alternative to conventional diets.
A double-blind RCT suggests pomegranate peel extract may improve liver enzymes, lipid profile, and inflammation in NAFLD patients, but does not significantly alter liver steatosis grade.
Flaxseed powder supplementation shows promise in improving liver fat, lipid metabolism, and inflammation in NAFLD and related metabolic disorders, with effects on gut microbiota but limited synergism with fasting mimicking diets.
The LOCATE-NAFLD trial demonstrates that nurse-delivered, community-based liver screening is highly acceptable and effective for identifying high-risk MASLD patients, but faces challenges in sustainable adoption.