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Internal MedicineJAK inhibitorsmuscle wasting

Tofacitinib Reverses Muscle Loss in Rheumatoid Arthritis: Insights from the RAMUS Trial

By MedXY|Dec 19, 2025

The RAMUS study demonstrates that the JAK inhibitor tofacitinib significantly increases lower limb muscle volume in patients with rheumatoid arthritis, offering a potential explanation for associated creatinine elevations and a new therapeu

Internal MedicineJAK inhibitorsmuscle wasting

Tofacitinib and Muscle Volume: A Potential Paradigm Shift in Managing Rheumatoid Cachexia

By MedXY|Dec 19, 2025

The RAMUS study demonstrates that tofacitinib significantly increases lower limb muscle volume in rheumatoid arthritis patients, potentially explaining associated creatinine elevations and offering a new therapeutic avenue for combating mus

Indirect Calorimetry Reveals Hypermetabolism That Predicts Accelerated Muscle Loss and Energy Deficit Risk in ICU Patients
Critical Caremuscle wasting

Indirect Calorimetry Reveals Hypermetabolism That Predicts Accelerated Muscle Loss and Energy Deficit Risk in ICU Patients

By MedXY|Nov 6, 2025

Serial indirect calorimetry–measured hypermetabolism is independently associated with more rapid CT-quantified muscle wasting and higher risk of energy deficit in critically ill adults, suggesting personalized metabolic monitoring could gui

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