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This study delineates three unique molecular subtypes of cholangiocarcinoma via integrated multiomic and machine learning methodologies, highlighting TNK1 kinase as a promising targeted therapy in a metabolic subtype.
IBDome offers a comprehensive multiomic atlas integrating molecular, histopathological, and clinical data, advancing the understanding and precision treatment of Crohn’s disease and ulcerative colitis.
A post hoc analysis of the LEAN-TIME trial reveals that integrating gut microbiome and metabolomic data with clinical phenotypes significantly improves the prediction of weight loss and regain, offering a framework for precision weight mana