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Selective D1/D5 Agonism: TEMPO-3 Trial Positions Tavapadon as a Significant Advancement for Parkinson’s Motor Fluctuations
NeurologyDopamine AgonistMotor Fluctuations

Selective D1/D5 Agonism: TEMPO-3 Trial Positions Tavapadon as a Significant Advancement for Parkinson’s Motor Fluctuations

By MedXY|Mar 22, 2026

The Phase 3 TEMPO-3 trial demonstrates that tavapadon, a selective D1/D5 agonist, significantly increases ‘good-on-time’ and reduces ‘off-time’ in Parkinson’s patients with motor fluctuations, offering a favorable sa

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