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Anesthesiology

Inhaled Methoxyflurane Matches or Exceeds Standard Analgesics for Rapid Prehospital Pain Relief: Results from the PreMeFen Randomised Trial

The PreMeFen trial found inhalational methoxyflurane provided rapid, clinically meaningful pain relief at 10 minutes and was non-inferior to intranasal fentanyl and intravenous morphine in the prehospital setting, offering a practical non‑i

Nov 28, 2025
news

Morphine Does Not Relieve Chronic Breathlessness: The MABEL Trial Finds No Benefit and Signals More Harms

A UK multicentre randomized placebo‑controlled trial (MABEL) showed no improvement in worst breathlessness with low‑dose oral morphine versus placebo at 28 days, with more adverse events and withdrawals in the morphine arm.

Nov 24, 2025
Clinical Updates

Low-Dose Morphine in COPD: Balancing Breathlessness Relief Against Sleep-Related Respiratory Risks

A randomized crossover trial reveals low-dose morphine in COPD does not improve sleep efficiency or breathlessness but may cause nocturnal hypoventilation, raising safety concerns despite unchanged next-day alertness.

Sep 19, 2025

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