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This study establishes transthyretin amyloid cardiomyopathy-specific mitral regurgitation thresholds, revealing lower severity cutoffs than guidelines and enhancing mortality and heart failure hospitalization risk prediction.
This propensity-matched study shows that in patients undergoing tricuspid TEER for severe TR, untreated moderate MR is linked to worse survival, while combined mitral and tricuspid TEER improves mortality and functional outcomes, highlighti
This 25-year prospective study evaluates the prognostic value of quantified mitral regurgitation (MR) severity and shows that early surgical intervention in upper-moderate MR improves long-term survival in asymptomatic patients.
A large-scale registry analysis demonstrates that Transcatheter Edge-to-Edge Repair (TEER) significantly reduces mortality and heart failure hospitalizations in patients with atrial functional mitral regurgitation (AFMR) compared to medical
This article examines the debate between JACC and ESC definitions for Atrial Functional Mitral Regurgitation (AfMR), highlighting why the JACC Expert Consensus offers a more robust framework for clinical prognosis and patient classification
This article explores the critical differences between JACC and ESC definitions for Atrial Functional Mitral Regurgitation (AfMR), highlighting how the JACC Consensus provides a more robust prognostic framework for managing this emerging he
The REVEAL-HCM study demonstrates that the prognostic impact of mitral regurgitation varies significantly across HCM subtypes, with notable risk in nonobstructive and apical forms, but not in obstructive or end-stage HCM.
The REVEAL-HCM study demonstrates that while mitral regurgitation is a frequent comorbidity in hypertrophic cardiomyopathy, its prognostic impact is highly subtype-specific, significantly affecting outcomes in non-obstructive subtypes but s
The RESHAPE-HF2 trial reveals that mitral transcatheter edge-to-edge repair (M-TEER) significantly reduces cardiovascular risks and enhances health status across all baseline patient conditions, reinforcing its role as a key intervention fo
An international study developed AI-ECG models that diagnose and predict future moderate–severe mitral, tricuspid, and aortic regurgitation, validated across distinct populations and linked to subclinical chamber remodelling.
A multicountry, single‑arm pivotal trial of the SAPIEN M3 transseptal transcatheter mitral valve replacement (TMVR) in patients deemed unsuitable for surgery or TEER demonstrated a 1‑year composite rate of death or heart‑failure rehospitali
The MITRACURE registry reveals late-stage referral and suboptimal early intervention in mitral regurgitation surgery, highlighting the need for improved management strategies to enhance repair rates and reduce mortality.
The MITRACURE international registry reveals that mitral valve surgery patients often present late in disease progression with advanced symptoms, showing modest repair rates and notable in-hospital mortality, underscoring the need for earli
