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MedXY AI/MedXY News/Tag: mitophagy
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HSP72-PRDX6 Control of PINK1 Ubiquitination Emerges as a New Mitophagy Axis in MASLD
GastroenterologyHSP72MASLD

HSP72-PRDX6 Control of PINK1 Ubiquitination Emerges as a New Mitophagy Axis in MASLD

By MedXY|May 1, 2026

A new Hepatology study identifies an HSP72–PRDX6 pathway that restores PINK1/Parkin mitophagy, reduces hepatic steatosis, and worsens MASLD when disrupted in mice and hepatocytes.

Breaking the Brake: How Annexin A2 Inhibition Restores Mitophagy and Salvages the Infarcted Heart
CardiologyAnnexin A2mitophagy

Breaking the Brake: How Annexin A2 Inhibition Restores Mitophagy and Salvages the Infarcted Heart

By MedXY|Mar 25, 2026

This study identifies Annexin A2 as a critical negative regulator of PHB2-mediated mitophagy in myocardial infarction. By promoting PHB2 degradation via the TRIM29 ligase, ANXA2 exacerbates cardiac injury. Inhibiting ANXA2 restores mitochon

Unlocking Mitochondrial Resilience: How Annexin A2 Inhibition Protects the Infarcted Heart
CardiologyAnnexin A2mitophagy

Unlocking Mitochondrial Resilience: How Annexin A2 Inhibition Protects the Infarcted Heart

By MedXY|Mar 21, 2026

Researchers identify Annexin A2 as a key inhibitor of mitophagy in the heart. By blocking the mitophagy receptor PHB2, ANXA2 exacerbates cardiac injury after myocardial infarction. This study demonstrates that targeting ANXA2 restores mitoc

Urolithin A for Muscle Health: A 4‑Month Randomized Trial Shows Improved Lower‑Limb Strength, Endurance Signals, and Mitochondrial Biomarkers
Clinical Updatesmitochondriamitophagy

Urolithin A for Muscle Health: A 4‑Month Randomized Trial Shows Improved Lower‑Limb Strength, Endurance Signals, and Mitochondrial Biomarkers

By MedXY|Oct 2, 2025

In a randomized, double‑blind 4‑month trial of middle‑aged overweight adults, oral urolithin A improved hamstring strength (~10–12%), increased peak VO2 and 6‑minute walk distance (clinically meaningful at 33 m for 1,000 mg), altered mitoch

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