Methylphenidate

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Methylphenidate for ADHD in Children and Adolescents: Modest Symptom Gains but Uncertain Net Benefit

Updated Cochrane analysis (212 RCTs, 16,302 participants) finds methylphenidate may reduce teacher-rated ADHD symptoms and improve general behaviour but increases non‑serious adverse events; overall evidence certainty is very low.

Dec 16, 2025

Internal Medicine

Evaluating Methylphenidate for Fatigue Management in Advanced Cancer: Insights from the MePFAC Randomized Controlled Trial

The MePFAC trial demonstrates that methylphenidate is safe but does not significantly reduce fatigue compared to placebo in advanced cancer patients receiving palliative care, challenging previous assumptions about its efficacy.

Oct 21, 2025