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Tocilizumab Reduces Major Cardiovascular Events Risk in Giant Cell Arteritis: Insights from a Nationwide French Cohort
Cardiologytocilizumabcardiovascular risk

Tocilizumab Reduces Major Cardiovascular Events Risk in Giant Cell Arteritis: Insights from a Nationwide French Cohort

By MedXY|Sep 8, 2026

A nationwide observational study reveals tocilizumab use in giant cell arteritis significantly lowers major adverse cardiovascular events compared to methotrexate, highlighting its potential cardiovascular benefits beyond inflammation contr

Avelumab Plus Methotrexate in Low-Risk Gestational Trophoblastic Tumors: A Promising First-Line Signal From TROPHAMET
newsgestational trophoblastic tumors
immunotherapy

Avelumab Plus Methotrexate in Low-Risk Gestational Trophoblastic Tumors: A Promising First-Line Signal From TROPHAMET

By MedXY|Aug 18, 2026

TROPHAMET found that first-line avelumab plus methotrexate achieved 96.2% hCG normalization in low-risk gestational trophoblastic tumors with manageable toxicity, no relapses at 41 months, and preserved fertility.

Aggressive Initial Management in Early Psoriatic Arthritis: Does Adding Golimumab to Methotrexate and Steroids Offer Superior Outcomes?
DermatologyGolimumabmethotrexate

Aggressive Initial Management in Early Psoriatic Arthritis: Does Adding Golimumab to Methotrexate and Steroids Offer Superior Outcomes?

By MedXY|Jan 13, 2026

The GOLMePsA trial found no significant difference in disease activity at 24 weeks when adding golimumab to methotrexate and steroids for early PsA. However, the triple therapy significantly reduced the need for rescue corticosteroids, high

Diagnosing and Managing Methotrexate-Induced Osteopathy in Rheumatologic Practice
newsmethotrexateosteopathy

Diagnosing and Managing Methotrexate-Induced Osteopathy in Rheumatologic Practice

By MedXY|Oct 9, 2025

Methotrexate-induced osteopathy, predominantly affecting postmenopausal women with rheumatoid or psoriatic arthritis, presents as stress fractures in the lower limbs. Early MRI or bone scintigraphy aids diagnosis, and discontinuing methotre

Dual JAK and ROCK Inhibition with CPL’116: A Promising Advance for Methotrexate-Refractory Rheumatoid Arthritis
Allergy & Immunologyclinical trialJAK inhibitor

Dual JAK and ROCK Inhibition with CPL’116: A Promising Advance for Methotrexate-Refractory Rheumatoid Arthritis

By MedXY|Oct 5, 2025

CPL’116, a novel dual JAK and ROCK inhibitor, demonstrates dose-dependent efficacy and a favorable safety profile in rheumatoid arthritis patients inadequately responsive to methotrexate, without the typical lipid or creatine kinase a

PANLAR 2025 Recommendations for Polyarticular Juvenile Idiopathic Arthritis in Latin America — Practical, Evidence-Based Guidance for Resource-Variable Settings
Allergy & Immunologybiologicsjuvenile idiopathic arthritis

PANLAR 2025 Recommendations for Polyarticular Juvenile Idiopathic Arthritis in Latin America — Practical, Evidence-Based Guidance for Resource-Variable Settings

By MedXY|Oct 4, 2025

PANLAR’s 2025 evidence-based recommendations for non-systemic polyarticular JIA emphasize early treat-to-target care using methotrexate, targeted escalation to biologics when needed, region-sensitive alternatives (leflunomide, triple nbDMAR

Curcumin Mitigates Methotrexate-Induced Ovarian Damage: Insights into Antioxidant Protection via PARP-1 and P53 Modulation
Clinical Updatesantioxidantcurcumin

Curcumin Mitigates Methotrexate-Induced Ovarian Damage: Insights into Antioxidant Protection via PARP-1 and P53 Modulation

By MedXY|Aug 6, 2025

Curcumin pretreatment reduces methotrexate-induced ovarian damage in rats by regulating oxidative stress and apoptosis pathways, highlighting a potential strategy for fertility preservation in chemotherapy.

Comparative Efficacy and Safety of Prednisone and Methotrexate as First-Line Treatments for Pulmonary Sarcoidosis
newsfirst-line treatmentmethotrexate

Comparative Efficacy and Safety of Prednisone and Methotrexate as First-Line Treatments for Pulmonary Sarcoidosis

By MedXY|Sep 30, 2025

A recent multicenter trial demonstrates methotrexate’s noninferiority to prednisone in improving lung function at 24 weeks in pulmonary sarcoidosis, with distinct side-effect profiles informing treatment choices.

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