Metabolic Reprogramming

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Mitochondrial Transfer via Tunneling Nanotubes: A Novel Mechanism of Macrophage-Mediated Immunosuppression in Pediatric AML

Mitochondrial transfer from pediatric AML blasts to macrophages via tunneling nanotubes induces metabolic and immunosuppressive reprogramming, impairing anti-leukemic immune responses and supporting chemoresistance, revealing potential targ

Oct 19, 2026

Infectious Diseases

HBV-Induced Immunosuppressive Macrophages: Metabolic and Epigenetic Pathways Driving Chronic Hepatitis B Persistence

This article reviews recent evidence on how HBV manipulates monocyte-to-macrophage differentiation through metabolic and epigenetic reprogramming, facilitating immunosuppression and chronic infection.

Sep 21, 2026

Cardiology

Targeting the CCND1-PDK4 Axis to Promote Reparative Macrophage Phenotype and Mitigate Post-Myocardial Infarction Cardiac Remodeling

This article discusses the role of cyclin D1 (CCND1) in promoting reparative macrophage transition post-myocardial infarction, highlighting its therapeutic potential in reducing adverse cardiac remodeling through metabolic reprogramming.

Sep 19, 2026Sign in to read