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High-impact physical activity in patients with hip osteoarthritis is associated with a reduced 12-month risk of total hip replacement, without increasing knee replacement risk in knee OA patients. Functional capacity partly mediates this be
The SELECT trial demonstrates semaglutide’s 20% reduction in major cardiovascular events in adults with obesity and cardiovascular disease. Mediation analysis reveals partial but uncertain roles of weight, inflammation, and glycemic m
This mediation analysis of a phase 2 MASH trial reveals that survodutide improves liver inflammation and fibrosis predominantly through weight-independent mechanisms, highlighting a potential direct hepatic effect beyond weight reduction.
A mediation analysis of the randomized ECLS‑SHOCK trial found that VA‑ECMO increased moderate–severe bleeding and vascular complications but these events did not statistically mediate 30‑day mortality in patients with acute myocardial infar
A scoping review found sparse and inconsistent mediation analyses assessing cardiovascular disease as the pathway linking lifestyle factors to cognition; evidence is tentative for physical activity but urgent, better-designed studies are ne
Mediation analysis of INTERACT3 reveals that systolic blood pressure and blood glucose control are primary drivers of functional recovery benefits in acute intracerebral hemorrhage care bundles.
