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Safety Profile Favors Apixaban Over Rivaroxaban in High-Risk Patients with Atrial Fibrillation and Peripheral Artery Disease
Cardiologyanticoagulationatrial fibrillation

Safety Profile Favors Apixaban Over Rivaroxaban in High-Risk Patients with Atrial Fibrillation and Peripheral Artery Disease

By MedXY|Jan 5, 2026

A large-scale cohort study reveals that while rivaroxaban and apixaban offer similar protection against limb events and stroke in patients with AF and PAD, rivaroxaban is associated with a 55% higher risk of major bleeding, suggesting apixa

Apixaban in Subclinical Atrial Fibrillation: More Major Bleeds Driven by GI Events but Not by Intracranial or Fatal Hemorrhage
CardiologyApixabanmajor bleeding
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Apixaban in Subclinical Atrial Fibrillation: More Major Bleeds Driven by GI Events but Not by Intracranial or Fatal Hemorrhage

By MedXY|Nov 14, 2025

In ARTESiA patients with device-detected subclinical AF, apixaban reduced thromboembolism but increased major bleeding—primarily noncritical gastrointestinal events—while intracranial and fatal bleeding rates were similar to aspirin.

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