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This study reveals genotype-specific differences in atrial fibrillation (AF) risk among dilated cardiomyopathy (DCM) patients, highlighting LMNA mutations as a major predictor of incident AF and its association with worse clinical outcomes,
This review synthesizes recent advances in understanding the natural history of LMNA-related cardiomyopathies and introduces the first validated prediction model for severe heart failure events, enhancing early risk stratification and manag
This groundbreaking research identifies WNT5a-mediated aberrant actin filament dynamics as the novel mechanism driving cardiac pathogenic phenotypes in Emery-Dreifuss muscular dystrophy, opening new therapeutic avenues for this rare but dev
In 718 patients with pathogenic/likely pathogenic LMNA variants, truncating variants carried higher risk of malignant ventricular arrhythmia independent of position, while missense variants in the tail domain and exons 7–12 had lower arrhyt
