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Unraveling the KLF9-NR4A1-p38 MAPK Axis: A Novel Mechanism Linking Intermittent Hypoxia to MASLD in Obstructive Sleep Apnea
Gastroenterologyintermittent hypoxiaKLF9

Unraveling the KLF9-NR4A1-p38 MAPK Axis: A Novel Mechanism Linking Intermittent Hypoxia to MASLD in Obstructive Sleep Apnea

By MedXY|Jul 8, 2026

This study elucidates how KLF9 mediates intermittent hypoxia-induced MASLD by suppressing NR4A1 and p38 MAPK signaling, paving the way for targeted therapies in OSA-associated metabolic liver disease.

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