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Isoflurane-Based Inhaled Sedation for Acute Hypoxemic Respiratory Failure: Insights from the SAVE-ICU Randomized Clinical Trial

This review critically examines the SAVE-ICU trial assessing isoflurane inhaled sedation versus intravenous sedation in mechanically ventilated adults with acute hypoxemic respiratory failure, highlighting implications for clinical practice

Oct 19, 2026
Anesthesiology

Inhaled Isoflurane: A Noninferior Alternative to Midazolam for Pediatric ICU Sedation

A multicenter phase 3 trial finds inhaled isoflurane as effective as intravenous midazolam for sedation in mechanically ventilated children, with added benefits of reduced opioid use and faster extubation.

Jul 31, 2025

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