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Once-weekly IcoSema versus Daily Insulin Glargine U100 in Type 2 Diabetes: Evidence from the COMBINE 4 Phase 3b Trial and Related Advances

COMBINE 4 demonstrated that once-weekly IcoSema (icodec+semaglutide) offers superior glycemic control, weight reduction, and reduced hypoglycemia versus daily insulin glargine U100 in insulin-naive type 2 diabetes patients, supported by com

Aug 15, 2026
Diabetes & Endocrinology

Gender Differences in Hypoglycaemia Among Type 1 and Insulin-Treated Type 2 Diabetes: Insights from the Hypo-METRICS Study

This study evaluates gender-based differences in hypoglycaemia symptoms and frequency among people with type 1 and insulin-treated type 2 diabetes using continuous glucose monitoring in real-world settings.

Jun 24, 2026
Clinical Updates

High-Intensity Interval Exercise in Type 1 Diabetes: Stronger Protection Against Exercise-Related Glycaemic Decline in the Postabsorptive Than Postprandial State

This clinical update reviews a new randomized crossover trial and prior literature showing that high-intensity interval exercise can attenuate glucose decline and late hypoglycaemia in adults with type 1 diabetes, particularly when performe

Jun 9, 2026Sign in to read
Diabetes & Endocrinology

SSTR2 Antagonism Restored Glucagon Responses During Experimental Hypoglycaemia in Adults With Long-Standing Type 1 Diabetes

In a randomized crossover phase 1 study, the investigational SSTR2 antagonist ZT-01 increased glucagon responses during insulin-induced hypoglycaemia in adults with type 1 diabetes without treatment-related safety signals.

May 31, 2026

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