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Critical CareAcute liver failurehepatic encephalopathy

Therapeutic Plasma Exchange May Improve Transplant-Free Survival in Severe Amatoxin-Associated Acute Liver Failure

By MedXY|Nov 6, 2025

A multinational retrospective cohort found adjunctive plasma exchange was associated with higher 28‑day transplant-free survival in amatoxin-related ALF patients with grade ≥2 hepatic encephalopathy.

Clinical Updatescirrhosisfecal microbiota transplantation

The THEMATIC Trial: Advancing Microbiota Transplantation to Prevent Hepatic Encephalopathy Recurrence in Cirrhosis

By MedXY|Oct 8, 2025

The THEMATIC phase II trial demonstrates that fecal microbiota transplantation (FMT) is safe and reduces HE recurrence in cirrhosis, independent of dose, route, or donor diet, with gut microbiota engraftment linked to clinical outcomes.