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Unraveling Hepatitis B-Induced Liver Fibrosis: The Critical Role of Pyruvate, PPARα, and Reactive Oxygen Species
GastroenterologyHBVliver fibrosis

Unraveling Hepatitis B-Induced Liver Fibrosis: The Critical Role of Pyruvate, PPARα, and Reactive Oxygen Species

By MedXY|Jul 10, 2026

This article explores the mechanism by which HBV induces liver fibrosis through pyruvate-dependent ROS production and PPARα inhibition, highlighting novel therapeutic targets for chronic hepatitis B management.

CD16+ γδ T Cells: A Novel Player in HBV Viral Control Through Antibody-Dependent Cytotoxicity
GastroenterologyADCCHBV

CD16+ γδ T Cells: A Novel Player in HBV Viral Control Through Antibody-Dependent Cytotoxicity

© 2026 MedXY
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By MedXY|Apr 25, 2026

A study reveals CD16+ γδ T cells as key mediators of antibody-dependent cellular cytotoxicity in HBV infection, correlating with reduced viral replication and offering new therapeutic targets.

Potent Antiviral Activity of the Class-E Capsid Assembly Modulator ALG-000184 in Chronic Hepatitis B: Insights from a Phase 1 Randomized Trial
Clinical UpdatesALG-000184Capsid Assembly Modulator

Potent Antiviral Activity of the Class-E Capsid Assembly Modulator ALG-000184 in Chronic Hepatitis B: Insights from a Phase 1 Randomized Trial

By MedXY|Mar 2, 2026

This review synthesizes the Phase 1 trial findings of ALG-000184, a novel capsid assembly modulator, demonstrating significant multi-log reductions in HBV DNA and RNA with a favorable safety profile in chronic HBV patients.

HBsAg <100 IU/mL Identifies Inactive Chronic HBV Patients with HCC Risk Below Surveillance Threshold
GastroenterologyHBsAgHBV

HBsAg <100 IU/mL Identifies Inactive Chronic HBV Patients with HCC Risk Below Surveillance Threshold

By MedXY|Nov 6, 2025

A large Asian cohort study shows serum HBsAg &lt;100 IU/mL reliably identifies inactive chronic hepatitis B patients whose annual HCC risk is &lt;0.2%, potentially allowing de‑escalation of surveillance and informing partial HBV cure defini

Alcohol’s Amplifying Effect on HBV-Related Liver Cancer: New Insights into Metabolic Reprogramming
newsAlcoholHBV

Alcohol’s Amplifying Effect on HBV-Related Liver Cancer: New Insights into Metabolic Reprogramming

By MedXY|Oct 27, 2025

This article explores how alcohol consumption worsens HBV-induced hepatocellular carcinoma by promoting ER stress and lipid metabolic disturbances, highlighting potential therapeutic targets like LPLA2 and BMP.

SCG101: A Novel HBV-Specific TCR-T Therapy Shows Promising Results in Advanced HBV-Related Hepatocellular Carcinoma
Clinical UpdatesHBVhepatocellular carcinoma

SCG101: A Novel HBV-Specific TCR-T Therapy Shows Promising Results in Advanced HBV-Related Hepatocellular Carcinoma

By MedXY|Oct 6, 2025

SCG101, an HBV-specific T-cell receptor T-cell therapy, demonstrates significant antiviral and antitumour efficacy with a manageable safety profile in patients with advanced HBV-related hepatocellular carcinoma refractory to prior treatment

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