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Peer Support After Opioid Overdose: Randomized Trial Finds No Reduction in Future Adverse Events
Emergency Medicineemergency medicineharm reduction

Peer Support After Opioid Overdose: Randomized Trial Finds No Reduction in Future Adverse Events

By MedXY|Feb 11, 2026

A randomized clinical trial of the Relay peer-navigator intervention in New York City found no significant reduction in opioid-related adverse events compared to standard care, despite high patient satisfaction and the intervention’s

Fentanyl and Xylazine Dominate the Illicit Supply: New Multi-City Data Reveal Deepening Polysubstance Crisis
Infectious Diseasesharm reduction

Fentanyl and Xylazine Dominate the Illicit Supply: New Multi-City Data Reveal Deepening Polysubstance Crisis

By MedXY|Feb 10, 2026

This toxicological analysis of out-of-treatment people who inject drugs across five major US cities found that 93% tested positive for fentanyl, while xylazine prevalence surged in the Northeast, underscoring the critical need for real-time

Reducing Carcinogen Exposure in Smokers with Serious Mental Illness: Insights from a Randomized Controlled Trial of E-Cigarette Provision
Oncologye-cigarettesharm reduction

Reducing Carcinogen Exposure in Smokers with Serious Mental Illness: Insights from a Randomized Controlled Trial of E-Cigarette Provision

By MedXY|Oct 5, 2025

This RCT demonstrates that disposable e-cigarettes significantly reduce carcinogen levels short-term among smokers with serious mental illness, underscoring the need for behavioral support to sustain harm reduction.

Synthetic Opioid Overdose Deaths Among Youth Surge 168%: A Five-Year Analysis and Clinical Implications
Clinical Updatesfentanylharm reduction

Synthetic Opioid Overdose Deaths Among Youth Surge 168%: A Five-Year Analysis and Clinical Implications

By MedXY|Sep 30, 2025

Overdose deaths from synthetic opioids alone in U.S. youth aged 15–24 surged 168% between 2018 and 2022, now representing one-third of all youth OD fatalities. Clinical vigilance, harm reduction, and targeted prevention are urgently needed.

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