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A randomized clinical trial of the Relay peer-navigator intervention in New York City found no significant reduction in opioid-related adverse events compared to standard care, despite high patient satisfaction and the intervention’s
This toxicological analysis of out-of-treatment people who inject drugs across five major US cities found that 93% tested positive for fentanyl, while xylazine prevalence surged in the Northeast, underscoring the critical need for real-time
This RCT demonstrates that disposable e-cigarettes significantly reduce carcinogen levels short-term among smokers with serious mental illness, underscoring the need for behavioral support to sustain harm reduction.
Overdose deaths from synthetic opioids alone in U.S. youth aged 15–24 surged 168% between 2018 and 2022, now representing one-third of all youth OD fatalities. Clinical vigilance, harm reduction, and targeted prevention are urgently needed.
