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Cardiology

Loss of the Fibrinogen αC Region, Rather Than Hypofibrinogenemia Alone, Attenuates Experimental Arterial Thrombosis

Mouse and human observational data suggest that the fibrinogen αC region is a key determinant of arterial thrombosis under hypofibrinogenemic conditions, likely through platelet GPVI-dependent mechanisms.

Jun 6, 2026
Cardiology

Reticulated Platelets Drive Prothrombotic Signalling in Coronary Artery Disease — GPVI and PI3K Identified as Actionable Targets

A multidimensional study of 95 CAD patients shows that RNA-rich reticulated platelets exhibit a distinct prothrombotic transcriptomic and proteomic signature with upregulated GPVI and PI3K signalling; GPVI and PI3K inhibition reduced RP-dri

Dec 2, 2025

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