Cardiologyintermittent hypoxia心脏纤维化
GLI1 Activation in Intermittent Hypoxia: A Novel Mechanistic Link Driving Cardiac Fibrosis in Obstructive Sleep Apnea
By MedXY|Aug 25, 2026
This study reveals that intermittent hypoxia activates GLI1 transcription factor in cardiac fibroblasts, driving fibrosis via PKM2-mediated glycolysis, and highlights GLI1 as a promising therapeutic target in OSA-associated cardiac dysfunct