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Optimal Sleep Duration Mitigates Cognitive Decline and Dementia Risk in Focal Epilepsy: Insights from the UK Biobank Study
Neurologycognitive functiondementia risk

Optimal Sleep Duration Mitigates Cognitive Decline and Dementia Risk in Focal Epilepsy: Insights from the UK Biobank Study

By MedXY|Apr 25, 2026

A UK Biobank study reveals that optimal sleep (6-8 hours) improves executive function and reduces dementia risk in focal epilepsy patients, with effects surpassing those in stroke patients. Nonoptimal sleep exacerbates cognitive deficits up

Cenobamate Outperforms Brivaracetam, Lacosamide, and Perampanel in Real-World Focal Epilepsy Management
Neurologyantiseizure medicationsCenobamate

Cenobamate Outperforms Brivaracetam, Lacosamide, and Perampanel in Real-World Focal Epilepsy Management

By MedXY|Feb 10, 2026

A large multicenter real-world study indicates that cenobamate provides superior effectiveness and seizure freedom rates compared to brivaracetam, lacosamide, and perampanel in adults with drug-resistant focal epilepsy, despite a higher inc

Extratemporal epilepsy, obesity and male sex predict SUDEP risk in drug‑resistant focal epilepsy: clinical insights from the REPO2MSE prospective case‑control study
Neurologybiomarkersfocal epilepsy

Extratemporal epilepsy, obesity and male sex predict SUDEP risk in drug‑resistant focal epilepsy: clinical insights from the REPO2MSE prospective case‑control study

By MedXY|Dec 1, 2025

A multicentre prospective nested case‑control analysis (REPO2MSE) identifies extratemporal seizure onset, BMI ≥30, male sex, and predominantly nocturnal seizures as independent SUDEP risk factors in drug‑resistant focal epilepsy; peri‑ictal

Real-world brivaracetam shows durable retention and early patient-reported benefits in difficult-to-control focal seizures
Neurologyfocal epilepsypatient-reported outcomes

Real-world brivaracetam shows durable retention and early patient-reported benefits in difficult-to-control focal seizures

By MedXY|Dec 1, 2025

A 12-month US prospective observational study found brivaracetam retention at 12 months of 57% (intent-to-treat) and 72% among those with known treatment status, early improvement in seizure-related disability and PROMIS domains, and a safe

Delayed Seizure Control in Focal Epilepsy: Insights from the Human Epilepsy Project
Neurologyantiseizure medicationsfocal epilepsy

Delayed Seizure Control in Focal Epilepsy: Insights from the Human Epilepsy Project

By MedXY|Oct 5, 2025

New data reveal many patients with focal epilepsy experience seizures beyond the first treatment year, with nearly a quarter developing resistance to antiseizure medications, underscoring the need for optimized treatment strategies.

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