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A large randomized trial finds no difference in 90-day days alive and out of hospital between early vasopressors with restricted fluids versus higher fluids with delayed vasopressors in septic shock, though pulmonary edema was less frequent
A large multicenter study shows that balanced crystalloids administered before ICU admission in sepsis patients reduce 30-day mortality compared to saline, supporting early fluid choice’s impact on sepsis outcomes.
A randomized trial showed no significant differences in 6- and 12-month cognitive, physical, and quality of life outcomes between early restrictive and liberal fluid resuscitation in sepsis-induced hypotension.
This article reviews findings from the CLOVERS trial analyzing endothelial glycocalyx degradation in sepsis, demonstrating its strong association with mortality but showing no impact of liberal versus restrictive fluid resuscitation strateg
