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Balancing the Scale: Early Antipsychotic Dose Reduction Linked to Better Long-term Functioning Despite Short-term Relapse Risks
newsfirst-episode psychosisfunctional recovery

Balancing the Scale: Early Antipsychotic Dose Reduction Linked to Better Long-term Functioning Despite Short-term Relapse Risks

By MedXY|Jan 16, 2026

The HAMLETT trial demonstrates that early dose reduction after first-episode psychosis increases short-term relapse risk but correlates with superior functional outcomes at three to four years, suggesting a potential ‘learning effect&

Balancing Risks and Benefits: Early Antipsychotic Dose Reduction Versus Maintenance After First-Episode Psychosis Remission
Clinical Updatesantipsychoticsdose reduction

Balancing Risks and Benefits: Early Antipsychotic Dose Reduction Versus Maintenance After First-Episode Psychosis Remission

By MedXY|Oct 6, 2025

A randomized clinical trial reveals early dose reduction of antipsychotics after first-episode psychosis remission increases short-term relapse risk and lowers quality of life, but may improve long-term functioning over four years.

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