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Balancing the Scale: Early Antipsychotic Dose Reduction Linked to Better Long-term Functioning Despite Short-term Relapse Risks

The HAMLETT trial demonstrates that early dose reduction after first-episode psychosis increases short-term relapse risk but correlates with superior functional outcomes at three to four years, suggesting a potential ‘learning effect&

Jan 16, 2026
Clinical Updates

Balancing Risks and Benefits: Early Antipsychotic Dose Reduction Versus Maintenance After First-Episode Psychosis Remission

A randomized clinical trial reveals early dose reduction of antipsychotics after first-episode psychosis remission increases short-term relapse risk and lowers quality of life, but may improve long-term functioning over four years.

Oct 1, 2025

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