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This study identifies fibroblast-secreted Spondin-2 as a crucial mediator promoting the transition from metaplastic to dysplastic gastric epithelial cells, advancing understanding of early gastric carcinogenesis.
Stimulating TSH receptor antibodies enhance expression of TSHR and IGF-1R in fibroblasts via receptor recycling, elucidating mechanisms underlying thyroid eye disease and identifying potential therapeutic targets.
This study found that advanced high-grade serous ovarian cancers from short-term survivors had more fibroblasts and stromal invasion signals, while tumors from long-term survivors showed stronger immune pathways, suggesting the tumor microe
