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Shear Stress-Induced Endothelial HEG1 Signalling: A Novel Pathway Linking Blood Flow to Blood Pressure Regulation
Cardiologyblood pressureendothelial dysfunction

Shear Stress-Induced Endothelial HEG1 Signalling: A Novel Pathway Linking Blood Flow to Blood Pressure Regulation

By MedXY|Apr 17, 2026

Researchers identify HEG1 as a critical flow-sensitive endothelial protein that regulates blood pressure through CUL3-mediated degradation of PHACTR1, linking reduced shear stress in hypertension to impaired NO production and vascular dysfu

Taurochenodeoxycholic Acid: A Novel Metabolic Sentinel Reversing Obesity-Induced Endothelial Dysfunction via the FXR-PHB1-ATF4 Axis
Cardiologybile acidsendothelial dysfunction

Taurochenodeoxycholic Acid: A Novel Metabolic Sentinel Reversing Obesity-Induced Endothelial Dysfunction via the FXR-PHB1-ATF4 Axis

By MedXY|Mar 9, 2026

This study identifies TCDCA as a key metabolite that restores endothelial function in obesity. By activating the endothelial FXR-PHB1-ATF4 pathway, TCDCA enhances serine metabolism, offering a promising therapeutic strategy to mitigate card

Chronic Cannabis Use — Both Smoking and Edible THC Are Associated With Endothelial Dysfunction in Young Adults
Cardiologycannabisendothelial dysfunction

Chronic Cannabis Use — Both Smoking and Edible THC Are Associated With Endothelial Dysfunction in Young Adults

By MedXY|Dec 3, 2025

A cross-sectional study found lower brachial flow‑mediated dilation in chronic marijuana smokers and THC‑edible users versus nonusers; smoked cannabis sera also impaired VEGF‑stimulated NO production in endothelial cells, suggesting distinc

Invisible Invaders: How Microplastics May Accelerate Atherosclerosis — and Why Men Could Be at Greater Risk
Cardiologyatherosclerosiscardiovascular risk

Invisible Invaders: How Microplastics May Accelerate Atherosclerosis — and Why Men Could Be at Greater Risk

By MedXY|Nov 25, 2025

New animal research links oral microplastic exposure to dramatic increases in arterial plaque—especially in males—by injuring endothelial cells and provoking inflammation and oxidative stress.

One High‑Fat Meal, Four Hours: Rapid Impairment of Vascular Function and Brain Blood‑Flow Regulation
Medical Newsendothelial dysfunction

One High‑Fat Meal, Four Hours: Rapid Impairment of Vascular Function and Brain Blood‑Flow Regulation

By MedXY|Oct 2, 2025

A controlled study from the University of New South Wales shows a single high‑fat meal (130 g fat) produces marked postprandial hypertriglyceridaemia and measurable declines in systemic endothelial function and dynamic cerebral autoregulati

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