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Analysis of two large cohorts reveals no significant association between levodopa use and freezing of gait in Parkinson’s disease after adjusting for disease severity and duration, emphasizing the primary role of disease progression in this
This study identifies key nongenetic factors impacting disease onset and severity in hereditary ataxias SCA6 and SCA27B, highlighting environmental exposures and demographics as important modifiers beyond genetic mutations.
A Danish nationwide study reveals higher genetic risk scores for IBD predict more severe disease courses, including increased surgery rates, stronger medication needs, and worse inflammatory markers in both Crohn’s and ulcerative coli